[HTML][HTML] The mechanisms behind rapid antidepressant effects of ketamine: a systematic review with a focus on molecular neuroplasticity
… neurotransmitters, neuromodulatory regulators, or from a trigger … , ketamine administration
also increases the AMPA to NMDA … -95, the target of GSK-3 that would promote AMPA-GluA1 …
also increases the AMPA to NMDA … -95, the target of GSK-3 that would promote AMPA-GluA1 …
Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes
GSB Viana, EM Do Vale, ARA de Araujo… - Brazilian Journal of …, 2020 - SciELO Brasil
… GSK-3: a key regulatory target for ketamine's rapid antidepressant effects mediated by
enhanced AMPA to NMDA throughput. Bipolar Disord 2016; 18: 702–705, doi: 10.1111/bdi.12452…
enhanced AMPA to NMDA throughput. Bipolar Disord 2016; 18: 702–705, doi: 10.1111/bdi.12452…
Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression
YT Wang, XL Wang, ST Feng, NH Chen… - Pharmacological …, 2021 - Elsevier
… signaling can inhabit GSK-3 activity; GSK-3 can inhibit mTOR … In conclusion, since
ketamine-induced side effects must be … nonselective NMDA receptor antagonist that activates …
ketamine-induced side effects must be … nonselective NMDA receptor antagonist that activates …
Preclinical models of treatment-resistant depression: challenges and perspectives
M Kolasa, A Faron-Górecka - Pharmacological Reports, 2023 - Springer
… The goal of the article is to contribute to better understanding and treatment of TRD, which
… kinase 3 (GSK-3) and AMPA receptors in the antidepressant effects of ketamine are also …
… kinase 3 (GSK-3) and AMPA receptors in the antidepressant effects of ketamine are also …
… )-ketamine a potential therapeutic agent for treatment-resistant depression with less detrimental side effects? A review of molecular mechanisms underlying ketamine …
E Scotton, B Antqueviezc, MF de Vasconcelos… - Biochemical …, 2022 - Elsevier
… target of rapamycin (mTOR), extracellular signal-regulated kinase (… Hypothetically, these
pyramidal neurons rely on AMPA … , phosphorylation of GSK-3 might be caused by the ketamine-…
pyramidal neurons rely on AMPA … , phosphorylation of GSK-3 might be caused by the ketamine-…
Insights into the Neurobiology of Suicidality: Explicating the role of glutamatergic systems through the lens of ketamine
AT Can, JS Mitchell, M Dutton… - Psychiatry and …, 2023 - Wiley Online Library
… targeting BDNF and Trk-B with ketamine treatment147, 148. … linked to improvement of AMPA
throughput, and followed by … GSK-3 inhibitor lithium enhances the antidepressant effects …
throughput, and followed by … GSK-3 inhibitor lithium enhances the antidepressant effects …
The ketamine antidepressant story: new insights
TK Alshammari - Molecules, 2020 - mdpi.com
… The aim of this study was to summarize and highlight the … non-NMDA-mediated affects
of ketamine are summarized in … , AMPA was found to be an essential element in mediating …
of ketamine are summarized in … , AMPA was found to be an essential element in mediating …
Glycogen synthase kinase-3 as a key regulator of cognitive function
X Fan, Z Zhao, D Wang, J Xiao - Acta biochimica et biophysica …, 2020 - academic.oup.com
… the structure of GSK-3, the regulation of GSK-3 activity, and … of NMDA receptor-mediated
signaling by ketamine evoked … apparent that GSK-3 is a promising therapeutic target due to its …
signaling by ketamine evoked … apparent that GSK-3 is a promising therapeutic target due to its …
Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?
JD Manduca, RK Thériault, ML Perreault - Pharmacological Research, 2020 - Elsevier
… and potential downstream targets of GSK-3 that may … Thus, in this review, increased
activation of GSK-3 coincident … active form of GSK-3, the antidepressant effects of ketamine were …
activation of GSK-3 coincident … active form of GSK-3, the antidepressant effects of ketamine were …
Ketamine: a tale of two enantiomers
… administrations and cognitive performance was generally found to … GSK-3 as an important
regulatory target for ketamine’s … Although NMDA receptor inhibition and subsequent AMPA …
regulatory target for ketamine’s … Although NMDA receptor inhibition and subsequent AMPA …